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Article

Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.

Journal of pharmaceutical sciences - 1 Jan 2006

Fujita Tomoe, Urban Thomas J, Leabman Maya K, Fujita Kazumi, Giacomini Kathleen M

Abstract excerpt

The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major transporter in the active secretion of organic cations in the kidney. Uptake of organic cations by OCT2 is driven by...

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Identifiers

PMID: 16307453
DOI: 10.1002/jps.20536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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