Article

EpiTox: A Multi-Modular Framework for Population-Aware Off-Target Prediction Highlighting MAGEA3 Cross-Reactivity

2025-12-12

Abstract excerpt

Targeting intracellular tumor antigens presented by peptide human leukocyte antigen (pHLA) complexes offers a promising immunotherapeutic strategy for patients with limited treatment options. However, development of pHLA-targeted drugs such as T-cell receptor (TCR) mimic antibodies (TCRm) and TCR-based therapeutics remains challenging due to severe offtumor and off-target toxicities arising from incomplete pHLA of...

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Literature Corpus work: 1d5b01b5-ba07-5b84-a703-7cfd9f5875b7
DOI: 10.64898/2025.12.10.693357

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