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Article

Broadening alloselectivity of T cell receptors by structure guided engineering.

Scientific reports - 6 Nov 2024

Karuppiah Vijaykumar, Sangani Dhaval, Whaley Lorraine, Pengelly Robert, Uluocak Pelin, Carreira Ricardo J, Hock Miriam, Cristina Pietro Della, Bartasun Paulina, Dobrinic Paula, Smith Nicola, Barnbrook Keir, Robinson Ross A, Harper Stephen

Abstract excerpt

Specificity of a T cell receptor (TCR) is determined by the combination of its interactions to the peptide and human leukocyte antigen (HLA). TCR-based therapeutic molecules have to date targeted a single peptide in the context of a single HLA allele. Some peptides are presented on multiple HLA alleles, and by engineering TCRs for specific recognition of more than one allele, there is potential to expand the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39500929
DOI: 10.1038/s41598-024-75140-7
PMCID: PMC11538495

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