Targeting of intracellular oncoproteins with peptide-centric CARs.

doi:10.1038/s41586-023-06706-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeting of intracellular oncoproteins with peptide-centric CARs.

Nature - 1 Nov 2023

Yarmarkovich Mark, Marshall Quinlen F, Warrington John M, Premaratne Rasika, Farrel Alvin, Groff David, Li Wei, di Marco Moreno, Runbeck Erin, Truong Hau, Toor Jugmohit S, Tripathi Sarvind, Nguyen Son, Shen Helena, Noel Tiffany, Church Nicole L, Weiner Amber, Kendsersky Nathan, Martinez Dan, Weisberg Rebecca, Christie Molly, Eisenlohr Laurence, Bosse Kristopher R, Dimitrov Dimiter S, Stevanovic Stefan, Sgourakis Nikolaos G, Kiefel Ben R, Maris John M

Abstract excerpt

The majority of oncogenic drivers are intracellular proteins, constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual human leukocyte antigen (HLA) allotypes1. However, most cancers have a modest mutational burden that is insufficient for generating responses using neoantigen-based therapies2,3. Neuroblastoma is a paediatric cancer that harbours few mutations and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Neoplasm

Share to Carcinogenesis

Share to Cross Reactions

Share to HLA-A Antigens

Share to Neuroblastoma

Share to Oncogene Proteins

Share to Receptors, Chimeric Antigen

Source

Open in PubMed Open full text

Identifiers

PMID: 37938771
DOI: 10.1038/s41586-023-06706-0
PMCID: PMC10665195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting of intracellular oncoproteins with peptide-centric CARs.PMID 37938771Read ↗

Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansionSemantic proximity Read ↗

A generalizable system for antigenic peptide targeting across HLA-I allotypesSemantic proximity Read ↗

Immunogenicity of a public neoantigen derived from mutated <i>PIK3CA</i>Semantic proximity Read ↗

Targeting peptide antigens using a multiallelic MHC I-binding system.Semantic proximity Read ↗

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.Semantic proximity Read ↗

Targeting Driver Oncogenes and Other Public Neoantigens Using T Cell Receptor–Based Cellular TherapySemantic proximity Read ↗

Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomicsSemantic proximity Read ↗

Tumor Antigens beyond the Human Exome.Semantic proximity Read ↗

Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentationSemantic proximity Read ↗

TCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical modelsSemantic proximity Read ↗

Tumour neoantigen repertoire computational predictions in malignant peripheral nerve sheath tumours define potential targets for immunotherapySemantic proximity Read ↗

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.