Article

Probing the hierarchical dynamics of DNA-sperm nuclear transition protein complex through fuzzy interaction and mesoscale condensation

2023-02-15

Abstract excerpt

Nuclear transition protein TNP1 is a crucial player mediating histone-protamine exchange in condensing spermatids. A unique combination of intrinsic disorder and multivalent properties turns TNP1 into an ideal agent for orchestrating the formation of versatile TNP-DNA assembly and endows the protein with potent value for vaccine design. Despite its significance, the physicochemical property and the molecular mecha...

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Literature Corpus work: 464b6eb9-bddc-5c4b-8ddd-050a173f6656
DOI: 10.1101/2023.02.14.528413

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