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FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins.

Nucleic acids research - 5 Jul 2022

Hatos Andras, Tosatto Silvio C E, Vendruscolo Michele, Fuxreiter Monika

Abstract excerpt

Many proteins perform their functions within membraneless organelles, where they form a liquid-like condensed state, also known as droplet state. The FuzDrop method predicts the probability of spontaneous liquid-liquid phase separation of proteins and provides a sequence-based score to identify the regions that promote this process. Furthermore, the FuzDrop method estimates the propensity of conversion of...

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PMID: 35610022
DOI: 10.1093/nar/gkac386
PMCID: PMC9252777

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