Article

Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain

2020-10-29

Abstract excerpt

Long Interspersed Nuclear Element-1 (LINE-1 or L1) is a retrotransposable element that autonomously replicates in the human genome, resulting in DNA damage and genomic instability. Activation of L1 in senescent cells triggers a type I interferon response and age-associated inflammation. Two open reading frames encode an ORF1 protein functioning as mRNA chaperone and an ORF2 protein providing catalytic activities n...

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Literature Corpus work: 302b3348-a644-5337-a08e-156eb8013a61
DOI: 10.1101/2020.10.29.360719

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