Article

SYNPO2L Isoforms Regulate the Action Potential Characteristics and Contractility of Atrial Cardiomyocytes via YAP Signaling to Modulate Atrial Fibrillation Risk

2025-08-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> SYNPO2L is a component of the sarcomere Z-disk with two distinct isoforms (SYNPO2L_A and SYNPO2L_B) described to regulate actin bundle size. Common and rare variations in SYNPO2L have been implicated in risk for heart failure and atrial fibrillation (AF); however, little is known about the function or pathophysiological mechanism upon disease risk. <h4>Methods</h4> The role...

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Literature Corpus work: 461813aa-26b3-5064-bcc1-8aebc58560b3
DOI: 10.1101/2025.08.03.668361

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