Article

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

2024-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Rare and common genetic variants contribute to the risk of atrial fibrillation (AF). Although ion channels were among the first AF candidate genes identified, rare loss-of-function variants in structural genes, such as TTN , have also been implicated in AF pathogenesis, partly through the development of atrial myopathy; however, the underlying mechanisms are poorly understood. While TTN trunca...

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Literature Corpus work: 07ccf337-d53a-54c8-8657-fe19087f196d
DOI: 10.1101/2024.12.06.24318402

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