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Article

Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the MYOZ1 and SYNPO2L Genes.

International journal of molecular sciences - 25 Sept 2024

Wass Sojin Y, Sun Han, Tchou Gregory, Liu Nana, Van Wagoner David R, Chung Mina K, Barnard John, Smith Jonathan D

Abstract excerpt

Genome-wide association studies have identified a locus on chromosome 10q22, where many co-inherited single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF). This study seeks to identify the impact of this locus on gene expression at the transcript isoform level in human left atria and to gain insight into potential causal variants. Bulk RNA sequencing was analyzed to identify myozenin...

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Identifiers

PMID: 39408638
DOI: 10.3390/ijms251910309
PMCID: PMC11477451

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