Article

Atrial fibrillation associated common risk variants in SYNE2 lead to lower expression of nesprin-2α1 and increased nuclear stiffness

2019-07-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Atrial fibrillation (AF) genome-wide association studies (GWAS) identified significant associations for rs1152591 and linked variants in the SYNE2 gene encoding the nesprin-2 protein that connects the nuclear membrane with the cytoskeleton <h4>Objective</h4> Determine the effects of the AF-associated rs1152591 and rs1152595, two linked intronic single nucleotide polymorphism...

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Literature Corpus work: 98ccbb10-6f4a-507a-bfa8-7c64e17089e7
DOI: 10.1101/708057

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