Article

Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

2023-03-03

Abstract excerpt

<h4>Background</h4> Protein truncating mutations in the titin gene are associated with increased risk of atrial fibrillation (AF). However, little is known regarding the underlying pathophysiology. <h4>Methods</h4> We identified a heterozygous titin truncating variant in a patient with unexplained early-onset AF using whole exome sequencing. We used atrial and ventricular patient induced pluripotent stem cell-de...

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Literature Corpus work: dbe8d8c0-1e74-59a2-a52b-f9f22b186ec3
DOI: 10.1101/2023.03.02.530843

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