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Engineering a pacemaker-driven human mini-heart guided by spatial and single cell multi-omics of sinoatrial node development

2026-05-12

Abstract excerpt

The human sinoatrial node (SAN) functions as the primary pacemaker of the heart and coordinates the hierarchical electrical activity that drives cardiac contraction. However, experimental systems capable of reconstructing pacemaker-driven cardiac organization in human tissues remain limited. Here we integrate spatial multi-omics of the human fetal SAN with stem-cell engineering to generate pacemaker organoids (“Si...

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Literature Corpus work
5d05facf-d084-5a51-96ff-4a64b5ba3d31
DOI
10.64898/2026.05.07.723626
Open publication

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Engineering a pacemaker-driven human mini-heart guided by spatial and single cell multi-omics of sinoatrial node developmentDOI 10.64898/2026.05.07.723626
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