Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

10 May 2010

Abstract excerpt

Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, often coexists with the related arrhythmia atrial flutter (AFL). Limitations in effectiveness and safety of current therapies make an understanding of the molecular mechanism underlying AF more urgent. Genome-wide association studies implicated a region of human chromosome 4q25 in familial AF and AFL, approximately 150 kb distal to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20457925
DOI: 10.1073/pnas.0912585107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationPMID 20457925Read ↗

<i>PITX2</i> Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to ArrhythmogenesisSemantic proximity Read ↗

PITX2-dependent gene regulation in atrial fibrillation and rhythm control.Semantic proximity Read ↗

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.Semantic proximity Read ↗

<i>Pitx2</i> , an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc GenesSemantic proximity Read ↗

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.Semantic proximity Read ↗

Multiple Roles of Pitx2 in Cardiac Development and DiseaseSemantic proximity Read ↗

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene ExpressionSemantic proximity Read ↗

Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.Semantic proximity Read ↗

Ventricular chamber-specific Pitx2 insufficiency leads to cardiac hypertrophy and arrhythmiasSemantic proximity Read ↗

The Long Noncoding RNA <i>Playrr</i> Regulates <i>Pitx2</i> Dosage and Protects Against Cardiac ArrhythmiasSemantic proximity Read ↗

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read ↗

A cellular atlas of <i>Pitx2-</i>dependent cardiac developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.