Common SYNE2 Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits.

doi:10.1161/CIRCGEN.124.004750

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Common SYNE2 Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits.

Circulation. Genomic and precision medicine - 1 Oct 2024

Liu Nana, Hsu Jeffrey, Mahajan Gautam, Sun Han, Laurita Kenneth R, Naga Prasad Sathyamangla V, Barnard John, Van Wagoner David R, Kothapalli Chandrasekhar R, Chung Mina K, Smith Jonathan D

Abstract excerpt

BACKGROUND: Atrial fibrillation GWAS (genome-wide association studies) identified significant associations for rs1152591 and linked variants in the SYNE2 gene encoding Nesprin-2, which connects the nuclear membrane with the cytoskeleton. METHODS: Reporter gene vector transfection and CRISPR-Cas9 editing were used to identify the causal variant regulating the expression of SYNE2α1. After SYNE2 knockdown or SYNE2α1...

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PMID: 39355904
DOI: 10.1161/CIRCGEN.124.004750
PMCID: PMC11522946

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