Article

Syncytium cell growth increases IK1 contribution in human iPS-cardiomyocytes

2019-12-03

Abstract excerpt

<h4>Summary</h4> Human induced pluripotent stem-cell-derived cardiomyocytes (hiPS-CMs) enable cardiotoxicity testing and personalized medicine. However, their maturity is of concern, including relatively depolarized resting membrane potential and more spontaneous activity compared to adult cardiomyocytes, implicating low or lacking inward-rectifier potassium current (Ik1). Here, protein quantification confirms Ik...

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Literature Corpus work: b2a37eb4-0414-50ac-af27-6f06bfd98dc1
DOI: 10.1101/862987

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