Article

Selective role of Nck1 in atherogenic inflammation and plaque formation

2019-06-11

Abstract excerpt

While CANTOS established the role of treating inflammation in atherosclerosis, our understanding of endothelial activation at atherosclerosis-prone sites remains limited. Disturbed flow at atheroprone regions primes plaque inflammation by enhancing endothelial NF-κB signaling. Herein, we demonstrate a novel role for the Nck adaptor proteins in disturbed flow-induced endothelial activation. Although highly similar,...

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Literature Corpus work: 4612324d-4283-5a58-ac67-d81fffbdcfd5
DOI: 10.1101/668129

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