Article

JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis

2020-05-16

Abstract excerpt

Endothelial cell (EC) sensing of fluid shear stress regulates atherosclerosis, a disease of arteries that causes heart attack and stroke. Atherosclerosis preferentially develops at regions of arteries exposed to low oscillatory shear stress (LOSS), whereas high shear regions are protected. We show using inducible EC-specific genetic deletion in hyperlipidaemic mice that the Notch ligands JAG1 and DLL4 have opposin...

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Literature Corpus work: 886b71a5-8069-515a-b36c-6a80eea6bb92
DOI: 10.1101/2020.05.15.097931

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