Article

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis

2025-03-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while the stable flow (s-flow) regions are protected even under hypercholesterolemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including the novel concept of partial endothelial-to-immune-cell-like tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b9246b6-2cd1-5651-a49d-f1dc237fc9c4
DOI: 10.21203/rs.3.rs-4397799/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during AtherogenesisDOI 10.21203/rs.3.rs-4397799/v1Read

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during AtherogenesisSemantic proximity Read

Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis.Semantic proximity Read

Identification of endothelial-to-mesenchymal transition gene signatures in single-cell transcriptomics of human atherosclerotic tissueSemantic proximity Read

Role of Flow-Sensitive Endothelial Genes in Atherosclerosis and Antiatherogenic Therapeutics Development.Semantic proximity Read

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis.Semantic proximity Read

Epsins oversee smooth muscle cell reprograming by influencing master regulators KLF4 and OCT4Semantic proximity Read

Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion CompositionSemantic proximity Read

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity Read

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid AtherosclerosisSemantic proximity Read

Coronary Artery Disease Transcriptomics Reveals Two Drivers of the Endothelial Cell SR-BI Expression and LDL Transport that Underlie AtherosclerosisSemantic proximity Read

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse AtherosclerosisSemantic proximity Read

Endothelial plasticity in atrial fibrosis by integrating single-cell sequencing and genetic lineage tracingSemantic proximity Read