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Article

Disturbed flow induces reprogramming of endothelial cells to immune-like and foam cells under hypercholesterolaemia during atherogenesis.

Cardiovascular research - 31 Dec 2025

Park Christian, Baek Kyung In, Hung Ruei-Chun, Choi Leandro, Jeong Kiyoung, Kim Paul, Jahng Andrew Keunho, Kim Jung Hyun, Kim Yerin, Meselhe Mostafa, Kannan Ashwin, Chou Chien-Ling, Kang Dong Won, Song Eun Ju, Bowman-Kirigin Jay Aaron, Clark Michael David, van der Laan Sander W, Pasterkamp Gerard, Villa-Roel Nicolas, Panitch Alyssa, Jo Hanjoong

Abstract excerpt

AIMS: Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while the stable flow (s-flow) regions are protected even under hypercholesterolaemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including the novel concept of partial endothelial-to-immune-cell-like transition (partial EndIT), but it was not...

Topics

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Carotid Artery, Common
Carotid Artery Diseases
Cellular Reprogramming
Foam Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypercholesterolemia

Plaque, Atherosclerotic

Regional Blood Flow

Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41288601
DOI: 10.1093/cvr/cvaf233
PMCID: PMC12860475

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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