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Article

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Wang Kuei-Chun, Yeh Yi-Ting, Nguyen Phu, Limqueco Elaine, Lopez Jocelyn, Thorossian Satenick, Guan Kun-Liang, Li Yi-Shuan J, Chien Shu

Abstract excerpt

The focal nature of atherosclerotic lesions suggests an important role of local hemodynamic environment. Recent studies have demonstrated significant roles of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in mediating mechanotransduction and vascular homeostasis. The objective of this study is to investigate the functional role of YAP/TAZ in the flow regulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27671657
DOI: 10.1073/pnas.1613121113
PMCID: PMC5068257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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