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Latrophilin-2 mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosis

2025-07-02

Abstract excerpt

Fluid shear stress (FSS) is a major determinant of endothelial cell (EC) phenotype, with physio-logical laminar FSS promoting arterial identity and stability, and disturbed FSS promoting atherosclerosis. We previously identified the adhesion G protein-coupled receptor (GPCR) Latrophilin-2 (LPHN2) as a junctional protein required for FSS activation of the PECAM1/VE-cadherin/VEGFR2/PlexinD1 junctional mechanosensory...

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Literature Corpus work
fd5f2536-f858-50de-85d4-ac17d57723ab
DOI
10.1101/2025.07.01.662676
Open publication

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Latrophilin-2 mediates flow activation of Notch to control vascular endothelial phenotype and atherosclerosisDOI 10.1101/2025.07.01.662676
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