Article

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis

2025-03-06

Abstract excerpt

<h4>Background</h4> Atherosclerosis occurs preferentially in the arteries exposed to disturbed flow (d-flow), while the stable flow (s-flow) regions are protected even under hypercholesterolemic conditions. We recently showed that d-flow alone initiates flow-induced reprogramming of endothelial cells (FIRE), including the novel concept of partial endothelial-to-immune-cell-like transition (partial EndIT), but was...

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Literature Corpus work: 04a66337-f6f9-5952-b67d-55875fb1102e
DOI: 10.1101/2025.03.06.641843

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