Article

DNA methylation signatures of mismatch repair-deficient colorectal cancer

2026-04-13

Abstract excerpt

<h4>Background</h4> Colorectal cancer (CRC) is a molecularly heterogeneous disease shaped by both genetic and epigenetic alterations. Approximately 15% of CRCs display widespread CpG island hypermethylation, known as the CpG Island Methylator Phenotype (CIMP). CIMP-high (CIMP-H) tumours frequently exhibit MLH1 promoter hypermethylation, leading to mismatch repair deficiency (MMRd) and microsatellite instability...

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Literature Corpus work: 45ffe4d2-048a-54a5-a7a4-a2fbf9fd7408
DOI: 10.64898/2026.04.09.717165

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