Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinicopathological and molecular characterization of deficient mismatch repair colorectal cancer.

Human pathology - 1 Dec 2022

Yamada Atsushi, Yamamoto Yoshihiro, Minamiguchi Sachiko, Kamada Mayumi, Sunami Tomohiko, Ohashi Shinya, Seno Hiroshi, Kawada Kenji, Muto Manabu

Abstract excerpt

Tumors demonstrating deficient mismatch repair (dMMR) account for 12%-15% of colorectal cancers (CRCs), but their characteristics have not been fully elucidated. The aim of this study was to characterize dMMR CRCs in terms of clinicopathological findings and molecular alterations. Immunostaining for mismatch repair (MMR) proteins was performed to determine MMR status, and then MLH1 promoter methylation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA Mismatch Repair

Share to Ligands

Share to MutL Protein Homolog 1

Share to Precancerous Conditions

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 36150551
DOI: 10.1016/j.humpath.2022.09.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinicopathological and molecular characterization of deficient mismatch repair colorectal cancer.PMID 36150551Read ↗

MLH1-deficient Colorectal Carcinoma With Wild-type BRAF and MLH1 Promoter Hypermethylation Harbor KRAS Mutations and Arise From Conventional Adenomas.Semantic proximity Read ↗

Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas.Semantic proximity Read ↗

Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.Semantic proximity Read ↗

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.Semantic proximity Read ↗

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.Semantic proximity Read ↗

Mismatch Repair Deficiency in Colorectal Adenocarcinoma: Clinical, Pathological and Prognostic Features, a Single Center’s Experience of 1002 CasesSemantic proximity Read ↗

Distinct Clinicopathological Patterns of Mismatch Repair Status in Colorectal Cancer Stratified by KRAS Mutations.Semantic proximity Read ↗

Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome.Semantic proximity Read ↗

[Clinicopathological features and prognosis of sporadic mismatch repair deficient colorectal cancer].Semantic proximity Read ↗

Deficient mismatch repair: Read all about it (Review)Semantic proximity Read ↗

Mismatch Repair Proficient Colorectal Adenocarcinoma in Two Patients With Lynch SyndromeSemantic proximity Read ↗

Clinicopathological features of mismatch repair protein expression patterns in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.