Article

<i>CREB3</i> gain of function variants protect against ALS

2024-10-11

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly evolving neurodegenerative disease that arises from the loss of glutamatergic corticospinal neurons (CSN) and cholinergic motoneurons (MN). The disease is mostly sporadic, but genetics is expected to highly contribute to disease onset and progression. Genome wide association studies identified a few genetic disease modifiers, mostly associated with a negat...

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Literature Corpus work: 45f65911-8289-5f3e-9b1f-9dd684815275
DOI: 10.1101/2024.10.10.617542

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