Back to search

Article

Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord

2025-08-30

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons, yet the cell-type specific molecular alterations within the spinal cords are not well characterized. In this study, we conducted deep molecular profiling of spinal cord tissues donated by people living with sporadic, C9orf72, and SOD1-ALS using single-nucleus RNA sequencing (snRNAseq). We obse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4bb5b796-779f-56d7-90c6-c08114de139b
DOI
10.1101/2025.08.26.672029
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cordDOI 10.1101/2025.08.26.672029
Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALSSemantic proximity
A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALSSemantic proximity
Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis.Semantic proximity
Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations.Semantic proximity
Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutationsSemantic proximity
Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapesSemantic proximity
CREB3 gain of function variants protect against ALSSemantic proximity
Endogenous retroviruses are dysregulated in ALSSemantic proximity
The New York Genome Center ALS Consortium resource integrates postmortem tissue transcriptomics and whole genome sequencing to empower biological discoverySemantic proximity
Integrative genetic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genesSemantic proximity
A Cellular Taxonomy of the Adult Human Spinal CordSemantic proximity
Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutationsSemantic proximity
Select a neighboring publication to make it the new centre.