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Divergent impacts of <i>C9orf72</i> repeat expansion on neurons and glia in ALS and FTD

2022-11-17

Abstract excerpt

Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are strongly influenced by inherited genetic variation, but environmental and epigenetic factors also play key roles in the course of these diseases. A hexanucleotide repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of ALS and FTD. To determine the cellular alterations associated wi...

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Literature Corpus work
d4428364-bcfd-53ab-9328-4c8723281637
DOI
10.1101/2022.11.17.516859
Open publication

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Divergent impacts of <i>C9orf72</i> repeat expansion on neurons and glia in ALS and FTDDOI 10.1101/2022.11.17.516859
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