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Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease.

Translational psychiatry - 26 Feb 2021

He Liang, Loika Yury, Park Yongjin, Bennett David A, Kellis Manolis, Kulminski Alexander M

Abstract excerpt

Despite recent discoveries in genome-wide association studies (GWAS) of genomic variants associated with Alzheimer's disease (AD), its underlying biological mechanisms are still elusive. The discovery of novel AD-associated genetic variants, particularly in coding regions and from APOE ε4 non-carriers, is critical for understanding the pathology of AD. In this study, we carried out an exome-wide association...

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Identifiers

PMID: 33637690
DOI: 10.1038/s41398-021-01263-4
PMCID: PMC7910483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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