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Elevated expression of<i>B4GALT6</i>,<i>GABRA1</i>,<i>GAD2</i>,<i>GLRA3</i>,<i>HTR2A</i>,<i>PCSK1</i>, and<i>SLC17A6</i>are postmortem markers for the ALS-Ox subtype

2024-03-22

Abstract excerpt

In this work, we stratify 428 bulk RNA-seq spinal cord transcriptomes from 206 ALS patients to assess concordance with cortical phenotype. We find the postmortem spinal cord generally recaptures the molecular phenotypes observed in the postmortem cortex and observe weaker differences in patient survival after correction for repeat measures. We compare intra-patient subtype assigned in the cortex and spinal cord, f...

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Literature Corpus work
a743177e-6055-59b3-949d-8948c920ff19
DOI
10.1101/2024.03.21.24304538
Open publication

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Elevated expression of<i>B4GALT6</i>,<i>GABRA1</i>,<i>GAD2</i>,<i>GLRA3</i>,<i>HTR2A</i>,<i>PCSK1</i>, and<i>SLC17A6</i>are postmortem markers for the ALS-Ox subtypeDOI 10.1101/2024.03.21.24304538
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