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Exome-wide age-of-onset analysis reveals exonic variants in <i>ERN1, TACR3</i> and <i>SPPL2C</i> associated with Alzheimer’s disease

2020-01-29

Abstract excerpt

Despite recent discovery in GWAS of genomic variants associated with Alzheimer’s disease (AD), its underlying biological mechanisms are still elusive. Discovery of novel AD-associated genetic variants, particularly in coding regions and from APOE ε4 non-carriers, is critical for understanding the pathology of AD. In this study, we carried out an exome-wide association analysis of age-of-onset of AD with ~20,000 su...

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Literature Corpus work
33f14706-2973-5d6e-ac58-e845bb5c3b0d
DOI
10.1101/2020.01.28.923789
Open publication

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Exome-wide age-of-onset analysis reveals exonic variants in <i>ERN1, TACR3</i> and <i>SPPL2C</i> associated with Alzheimer’s diseaseDOI 10.1101/2020.01.28.923789
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