Article

Wild-type <i>C9orf72</i> expression is a genetic modifier of C9-ALS survival

2026-02-09

Abstract excerpt

1 Amyotrophic lateral sclerosis (ALS) is highly heritable, yet the vast majority of cases lack an identifiable genetic cause and clinical progression remains largely unpredictable. To connect noncoding and rare genetic variation to disease phenotypes in a relevant cell type, we generated a multi-omic quantitative trait locus (QTL) atlas from 594 induced-pluripotent-stem-cell–derived human motor neuron lines (522 A...

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Literature Corpus work: a468e237-cd68-56d6-82ff-6cf9b5c47894
DOI: 10.64898/2026.02.06.26345684

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