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Article

Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use.

Molecular psychiatry - 1 Jul 2025

Aliev Fazil, De Sa Nogueira David, Aston-Jones Gary, Dick Danielle M

Abstract excerpt

The hypothalamic neuropeptide system of orexin (hypocretin) neurons provides projections throughout the neuraxis and has been linked to sleep regulation, feeding and motivation for salient rewards including drugs of abuse. However, relatively little has been done to examine genes associated with orexin signaling and specific behavioral phenotypes in humans. Here, we tested for association of twenty-seven genes...

Read the complete abstract on PubMed

Topics

Humans
Orexins
Male
Phenotype
Neuropeptides
Female
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Substance-Related Disorders

Adult

Orexin Receptors

Genetic Association Studies

Polymorphism, Single Nucleotide

Reward

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 39880903
DOI: 10.1038/s41380-025-02895-4
PMCID: PMC12185332

Genes

HCRT
PPOX
HCRTR2

Provenance

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