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Article

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.

Trends in neurosciences - 1 Oct 2012

Butelman Eduardo R, Yuferov Vadim, Kreek Mary Jeanne

Abstract excerpt

Addictions to cocaine or heroin/prescription opioids [short-acting μ-opioid receptor (MOPr) agonists] involve relapsing cycles, with experimentation/escalating use, withdrawal/abstinence, and relapse/re-escalation. κ-Opioid receptors (KOPr; encoded by OPRK1), and their endogenous agonists, the dynorphins (encoded by PDYN), have counter-modulatory effects on reward caused by cocaine or MOPr agonist exposure, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22709632
DOI: 10.1016/j.tins.2012.05.005
PMCID: PMC3685470

Genes

OPRK1
PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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