Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.

doi:10.1016/j.celrep.2017.02.052

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Article

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.

Cell reports - 14 Mar 2017

Obayashi Eiji, Luna Rafael E, Nagata Takashi, Martin-Marcos Pilar, Hiraishi Hiroyuki, Singh Chingakham Ranjit, Erzberger Jan Peter, Zhang Fan, Arthanari Haribabu, Morris Jacob, Pellarin Riccardo, Moore Chelsea, Harmon Ian, Papadopoulos Evangelos, Yoshida Hisashi, Nasr Mahmoud L, Unzai Satoru, Thompson Brytteny, Aube Eric, Hustak Samantha, Stengel Florian, Dagraca Eddie, Ananbandam Asokan, Gao Philip, Urano Takeshi, Hinnebusch Alan G, Wagner Gerhard, Asano Katsura

Abstract excerpt

During eukaryotic translation initiation, eIF3 binds the solvent-accessible side of the 40S ribosome and recruits the gate-keeper protein eIF1 and eIF5 to the decoding center. This is largely mediated by the N-terminal domain (NTD) of eIF3c, which can be divided into three parts: 3c0, 3c1, and 3c2. The N-terminal part, 3c0, binds eIF5 strongly but only weakly to the ribosome-binding surface of eIF1, whereas 3c1...

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PMID: 28297669
DOI: 10.1016/j.celrep.2017.02.052
PMCID: PMC5382721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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