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Article

Factor-dependent processivity in human eIF4A DEAD-box helicase

25 Jun 2015

Abstract excerpt

During eukaryotic translation initiation, the small ribosomal subunit, assisted by initiation factors, locates the messenger RNA start codon by scanning from the 5' cap. This process is powered by the eukaryotic initiation factor 4A (eIF4A), a DEAD-box helicase. eIF4A has been thought to unwind structures formed in the untranslated 5' region via a nonprocessive mechanism. Using a single-molecule assay, we found...

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PMID: 26113725
DOI: 10.1126/science.aaa5089

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