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Article

Structural basis for the enhancement of eIF4A helicase activity by eIF4G.

Genes & development - 15 Sept 2005

Oberer Monika, Marintchev Assen, Wagner Gerhard

Abstract excerpt

The eukaryotic translation initiation factors 4A (eIF4A) and 4G (eIF4G) are crucial for the assembly of the translationally active ribosome. Together with eIF4E, they form the eIF4F complex, which recruits the 40S subunit to the 5' cap of mRNA. The two-domain RNA helicase eIF4A is a very weak helicase by itself, but the activity is enhanced upon interaction with the scaffolding protein eIF4G. Here we show that,...

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Identifiers

PMID: 16166382
DOI: 10.1101/gad.1335305
PMCID: PMC1221891

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