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Article

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.

Nucleic acids research - 29 Oct 2014

Pisareva Vera P, Pisarev Andrey V

Abstract excerpt

48S initiation complex (48S IC) formation is the first stage in the eukaryotic translation process. According to the canonical mechanism, 40S ribosomal subunit binds to the 5'-end of messenger RNA (mRNA) and scans its 5'-untranslated region (5'-UTR) to the initiation codon where it forms the 48S IC. Entire process is mediated by initiation factors. Here we show that eIF5 and eIF5B together stimulate 48S IC...

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Identifiers

PMID: 25260592
DOI: 10.1093/nar/gku877
PMCID: PMC4231746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.PMID 25260592Read ↗

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