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Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translation

1 Apr 2024

Abstract excerpt

Messenger RNA (mRNA) recruitment to the 40S ribosomal subunit is mediated by eukaryotic initiation factor 4F (eIF4F). This complex includes 3 subunits: eIF4E (m 7 G cap binding protein), eIF4A (DEAD-box helicase), and eIF4G. Mammalian eIF4G is a scaffold that coordinates the activities of eIF4E and eIF4A and provides a bridge to connect the mRNA and 40S ribosomal subunit through its interaction with eIF3. While...

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PMID: 38569933
DOI: 10.1016/j.jbc.2024.107242

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