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Packaging of supplemented urokinase into naked alpha-granules of <i>in vitro</i> -grown megakaryocytes for targeted therapeutic delivery

2023-12-05

Abstract excerpt

Our prior finding that uPA endogenously expressed and stored in the platelets of transgenic mice prevented thrombus formation without causing bleeding, prompted us to develop a potentially clinically relevant means of generating anti-thrombotic human platelets in vitro from CD34 + hematopoietic cell-derived megakaryocytes. CD34 + -megakaryocytes internalize and store in α-granules single-chain uPA (scuPA) and a...

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Literature Corpus work
454a8876-3b2e-555f-9ae4-dc54489a60fb
DOI
10.1101/2023.12.05.570278
Open publication

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Packaging of supplemented urokinase into naked alpha-granules of <i>in vitro</i> -grown megakaryocytes for targeted therapeutic deliveryDOI 10.1101/2023.12.05.570278
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