Article

ATP11A and ATP11C are plasma membrane phosphatidylserine flippases in <i>in vitro</i> human megakaryocytes

2026-02-02

Abstract excerpt

Thrombotic diseases are the major worldwide cause of cardiovascular death. Platelets prevent blood loss following injury (haemostasis), but inappropriate and excessive platelet activation can lead to thrombosis. Platelet activation must be tightly controlled. Pro-coagulant platelets expose phosphatidylserine (PS), enabling coagulation complex assembly, enhancing thrombin generation and thrombosis. PS is normally r...

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Literature Corpus work: 21b4e47f-900d-5ba2-8b89-0e320b1af1c6
DOI: 10.64898/2026.01.30.702765

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