Article

RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects: Therapeutic implications

2022-09-14

Abstract excerpt

Heterozygous defects in runt-related transcription factor-1 (RUNX1) are causative of a familial platelet disorder with associated myeloid malignancy (FPDMM). Since RUNX1-deficient animal models do not mimic FPDMM’s bleeding disorder or leukemic risk, establishment of a proper model system is critical to understand the underlying mechanisms of the observed phenotype and to identify therapeutic interventions. We pre...

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Literature Corpus work: a1fab8b9-84c3-5a4c-b91e-5c0b65cab114
DOI: 10.1101/2022.09.12.507354

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