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Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells

16 Oct 2014

Abstract excerpt

Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for the production of transfusable platelets. Here, we describe a method to generate megakaryocytes (MKs) and functional platelets from iPSCs in a scalable manner under serum/feeder-free conditions. The method also permits the cryopreservation of MK progenitors, enabling a rapid "surge" capacity when large numbers of platelets...

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PMID: 25418726
DOI: 10.1016/j.stemcr.2014.09.010

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