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Article

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2017

Rothmeier Andrea S, Marchese Patrizia, Langer Florian, Kamikubo Yuichi, Schaffner Florence, Cantor Joseph, Ginsberg Mark H, Ruggeri Zaverio M, Ruf Wolfram

Abstract excerpt

OBJECTIVE: Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange. How these mechanisms contribute to keeping TF in a noncoagulant state and to generating prothrombotic TF remain incompletely understood. APPROACH AND RESULTS: Here, we study the activation of TF in primary macrophages by a...

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Identifiers

PMID: 28495929
DOI: 10.1161/ATVBAHA.117.309315
PMCID: PMC5501484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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