Article
Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2017
Beckers Cora M L, Simpson Kingsley R, Griffin Kathryn J, Brown Jane M, Cheah Lih T, Smith Kerrie A, Vacher Jean, Cordell Paul A, Kearney Mark T, Grant Peter J, Pease Richard J
Abstract excerpt
OBJECTIVE: To establish the cellular source of plasma factor (F)XIII-A. APPROACH AND RESULTS: A novel mouse floxed for the F13a1 gene, FXIII-Aflox/flox (Flox), was crossed with myeloid- and platelet-cre-expressing mice, and cellular FXIII-A mRNA expression and plasma and platelet FXIII-A levels were measured. The platelet factor 4-cre.Flox cross abolished platelet FXIII-A and reduced plasma FXIII-A to 23±3%...
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