Article

Reprogramming Megakaryocyte Gene Expression to Release Platelet-Like Particles with Opposite Biological Activities: Carrying Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic Potentials

2023-08-07

Abstract excerpt

In this study, we reported that novel single-chain fusion-proteins linked thromboxane A2 (TXA2) receptor (TP) to a selected G-protein α-subunit q (SC-TP-Gαq), or s (SC-TP-Gαs) could be stably expressed in megakaryocytes (MK). We tested the MK-released platelet-linked particles (PLPs) to be used as a vehicle to deliver the over-expressed SC-TP-Gαq), or s (SC-TP-Gαs) to regulate human platelet function. To understan...

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Literature Corpus work: 935c24eb-2e2c-5fcb-abdf-45286c3bdf88
DOI: 10.20944/preprints202308.0502.v1

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Reprogramming Megakaryocyte Gene Expression to Release Platelet-Like Particles with Opposite Biological Activities: Carrying Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic PotentialsDOI 10.20944/preprints202308.0502.v1Read

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