Article

A key regulator of missing-self innate immunity is polymorphic and under diversifying selection

2025-12-11

Abstract excerpt

Host-parasite co-evolution drives the diversification of host immune genes involved in the recognition of pathogen antigens and molecular patterns. In contrast, the immune genes involved in self-recognition and inhibition of immune responses against self-cells (missing-self immunity) are expected to be evolutionarily constrained. However, many pathogens, such as the Lyme disease agent Borrelia , hijack these gene...

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Literature Corpus work: 44e817eb-6312-5e64-9831-46d373ef6d73
DOI: 10.64898/2025.12.10.693425

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