Article
A 175 million year history of T cell regulatory molecules reveals widespread selection, with adaptive evolution of disease alleles.
Immunity - 27 Jun 2013
Forni Diego, Cagliani Rachele, Pozzoli Uberto, Colleoni Marta, Riva Stefania, Biasin Mara, Filippi Giulia, De Gioia Luca, Gnudi Federica, Comi Giacomo P, Bresolin Nereo, Clerici Mario, Sironi Manuela
Abstract excerpt
T cell activation plays a central role in immune response and in the maintenance of self-tolerance. We analyzed the evolutionary history of T cell regulatory molecules. Nine genes involved in triggering T cell activation or in regulating the ensuing response evolved adaptively in mammals. Several positively selected sites overlap with positions interacting with the binding partner or with cellular components....
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