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Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

29 Jul 2021

Abstract excerpt

Pathogens possess the ability to adapt and survive in some host species but not in others-an ecological trait known as host tropism. Transmitted through ticks and carried mainly by mammals and birds, the Lyme disease (LD) bacterium is a well-suited model to study such tropism. Three main causative agents of LD, Borrelia burgdorferi, B. afzelii, and B. garinii, vary in host ranges through mechanisms eluding...

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PMID: 34324600
DOI: 10.1371/journal.ppat.1009801

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