Article

CD36 homologs determine microbial resistance to the Lyme disease spirochete

2022-02-10

Abstract excerpt

Pattern recognition receptors sense pathogens in arthropods and mammals through distinct immune processes. Whether these molecules share a similar function and recognize the same microbe in evolutionarily distant species remain ill-defined. Here, we establish that the CD36 superfamily is required for Borrelia burgdorferi resistance in both the arthropod vector and humans. Using the blacklegged tick Ixodes scapul...

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Literature Corpus work: cf38e371-22fe-5719-ab4c-977cb80adb46
DOI: 10.1101/2022.02.09.479763

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